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Almost everyone who has ever used the stimulant Adderall, a combination drug for sleep disorder narcolepsy or attention deficit hyperactivity disorder (ADHD), is aware that the therapeutic effects of the drug are the highest when used for the first time. When used on a regular basis, its efficacy begins to deplete with time, reaching a stage when it has no impact on the user. Such a reduction in the neurophysiologic response caused by the usage of the drug over a long period of time is known as Adderall tolerance. When one's body adapts to the chemical makeup of Adderall, it becomes increasingly resistant to any kind of effects, which eventually leads to Adderall tolerance.