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The most likely candidate to replace codeine as king of the painkillers is Tramadol. This drug is a fully synthetic opioid and, as such, it has several advantages over other opioids. Whereas codeine "works" by binding to the opioid receptors in the brain and throughout the nervous system, Tramadol does more. It inhibits the reuptake of norepinephrine - the hormone that makes humans feel pain - and causes a release of serotonin, which makes humans feel good. It is also less addictive.

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